Effects of Xin Kang Injection on Cardiac Function of Rats with Adriamycin-induced Myocarditis
- VernacularTitle:心康注射液对心肌炎大鼠心功能的影响
- Author:
Hongli ZHAN
;
Dong JIA
;
Hong ZHANG
;
Jialin DU
;
Yue QI
;
Yanju ZHU
- Publication Type:Journal Article
- Keywords:
Xin Kang Injection;
Myocarditis;
Adriamycin;
Cardiac function
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Xin Kang Injection on cardiac function of rats with adriamycin-induced myocarditis and to explore its pharmacological mechanism.Methods Seventy Wistar rats were randomly divided into seven groups:normal control group,model group,three-dosage Xin Kang Injection groups(high-,moderate-and low-dosage respectively),deslanoside group,and Huangqi group.The myocarditis rat model was established by intraperitoneal injection of adriamycin.Left ventricular end-diastolic pressure(LVEDP),left ventricular systolic pressure(LVSP),heart rate(HR),T value,and ? DP/DTmax were observed.Results LVSP,+ DP/DTmax in the treatment groups were higher and-DP/DTmax lower than those in the model group(P
