Long-term Toxicity of Jiuxin Fumai Injection in Rats
- VernacularTitle:救心复脉注射液对大鼠的长期毒性试验
- Author:
Can LI
;
Daosheng HUANG
;
Bingwu ZHONG
;
Jiangang YANG
;
Zhaoquan SUN
;
Liyi LIU
- Publication Type:Journal Article
- Keywords:
Jiuxin Fumai Injection;
Synephrine;
N-methyltyramine;
Citrus anrantium L;
Rat;
Long-term toxicity
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the long-term toxicity of Jiuxin Fumai Injection and to investigate the safety of clinical medication.Methods The rats were given intramuscular injection with Jiuxin Fumai Injection in large,medium,small dosage(respectively 20,10,5g? kg-1)every day for two weeks,and normal saline group served as the normal control.Two weeks after drug withdrawal,the toxic reaction in rats was observed.Results After two-week continuous administration,all the animals were alive.Some animals were vomiting and getting excited when administered the large dosage and medium dosage injection.The blood sugar elevated,the thoracic gland coefficient lowered,the hepatic cells were cloudily swollen in the animals of large dosage group.Two weeks after drug withdrawal,the above phenomenon vanished.There was no obvious toxic reaction in the small-dosage injection group.Conclusion Long-term administration of Jiuxin Fumai Injection in large dosage shows certain toxic reaction in rats.The safe dosage for intramuscular administration is less than 5 g? kg-1? d-1.
