Therapeutic effect of Jianing Decoction on experimental autoimmune thyroiditis
- VernacularTitle:甲宁对实验性自身免疫性甲状腺炎的治疗作用
- Author:
Mingxia ZHANG
;
Xiaozhong LI
;
Haixia GAO
;
Yongjian ZHANG
- Publication Type:Journal Article
- Keywords:
Jianing Decoction (JN);
experimental autoimmune thyroiditis;
TGAb;
TPOAb;
rats
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the therapeutic effect of Jianing Decoction (Rhizoma sparganii, Rhizoma curcumae, Radix bupleuri, Fructus schisandrae chinensis, Spuama manis, Radix polygoni multifrori, Spica prunellae, Flos chrysanthemi indici, Fructus ligustri lucidi) (JN) on autoimmune thyroiditis. METHODS: An animal model of experimental autoimmune thyroiditis (EAT) in rats was developed by using thyroglobulin of porcine (PTg). These animals were divided into JN group, triptolide (TP) group and control group. Pathological changes were observed in the thyroid tissues and serum thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TGAb) were determined by the method of radiorimmuoussay. RESULTS: The serum TGAb and TPOAb were significantly higher in EAT model group than those in normal group (P
