Effect of HPMC on floatation and release of Zuojin Gastric Floating Sustained-release Tablet
- VernacularTitle:羟丙基甲基纤维素对左金胃漂浮缓释片的漂浮性能和药物释放特征的影响
- Author:
Xinhiu ZHAO
;
Taoshi LIU
;
Jinao DUAN
- Publication Type:Journal Article
- Keywords:
Zuojin Pellet;
gastric floating sustained-release tablet;
HPMC
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To elucidate the effect of HPMC on the floating and releasing performances of Zuojin Gastric Floating Sustained-Release Tablets(ZJ-GFST) and to select the optimum matrix adjuvant for ZJ-GFST. METHODS: Seven kinds of ZJ-GFST from pharmaceutical factories as main adjuvant respectively.The floating lag time and the sustained floating time were used to evaluate the floating performance of ZJ-GFST.The accumulative releasing rates of berberine and palmatine in vitro were used to evaluate the releasing efficiency of ZJ-GFST. RESULTS: The tablets prepared with HPMC MK-100000 and MK-15000 disintegrated quickly when contacting with water, and the tablets prepared with HPMC MK-100M and MK-4000 had too long floating lag time and low release speed.The tablets prepared with HPMC 60RT-50、K-4M and MK-1500 all possessed short floating lag time and long sustained floating time and suitable drug releasing rate. CONCLUSION: The selected HPMC is 60RT-50.
