Determination of phenytoin sodium and schisandrin in Compound Valpromide Capsule by HPLC
- VernacularTitle:HPLC测定复方丙戊酰胺胶囊中苯妥英钠和五味子醇甲的含量
- Author:
Pingping FU
;
Haoran JING
;
Zhiwei ZHAO
- Publication Type:Journal Article
- Keywords:
phenytoin sodium;
schisandrin;
Compound Valpromide Capsule;
HPLC
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a HPLC method for determining phenytoin sodium and schisandrin in Compound Valpromide Capsule(Valpromide,phenytoin sodium,Fructus Schisandrae Chinensis, VB_6,etc). METHODS: A Hypersil BDS ODS column was used.The mobile phase was MeOH-0.02 mol/L potassium Dihydrogen Phosphate(60∶40).The detection wavelength was at 254 nm. RESULTS: The linear range of phenytoin sodium was within 4.50 ?g-72.0 ?g(r=1.000 0),The linear range of schisandrin was within 0.024 4 ?g- 0.391 ?g(r=0.999 9).The average recoveries(n=9) were 100.21% and 102.32%,respectively.RSD were 1.3% and 0.5%,respectively. CONCLUSION: The method is simple,reliable,accurate and can be applied to the quality control of the preparation.
