Effect of Buzhong Yiqi Wan on Thyroid Hormones in Rat Model of Spleen-asthenia
- VernacularTitle:补中益气丸对脾虚大鼠甲状腺激素水平的影响
- Author:
Zhaoming ZENG
;
Zhixi CHEN
;
Hui ZHAO
;
Jinyan CHEN
;
Zhiqiang LI
- Publication Type:Journal Article
- Keywords:
BUZHONG YIQI WAN/pharmacology;
SPLEEN ASTHENIA/TCD therapy;
THYROID HORMONES/blood;
DISEASE MODELS,ANIMAL;
RATS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the effect of Buzhong Yiqi Wan(BYW)on thyroid hormones in rat model of spleen-asthenia.【Methods】Thirty-four SD male rats were randomized into 3 groups:normal control group(N=10),spleen-asthenia model group(N=12),BYW group(N=12).Except the normal control group,the rats in other groups were given the decoction of Radix et Rhizoma Rhei(4 g?d-1 for each rat)to induce spleen asthenia,and meanwhile,BYW group reveived BYW(3.9 g?kg-1?d-1).The treatment lasted 20 days.Radioimmunoassay was used to detect serum levels of triiodothyronine(T3),thyroxine(T4),reverse triiodothyronine(rT3)and thyroid stimulating hormone(TSH).Meanwhile,the body weight,spleen and thymus weight as well as their ratio with the body weight were also observed.【Results】Serum T3 and T4 levels,spleen and thymus weight as well as their ratio with the body weight were decreased in the model group as compared with those in the normal control group(P
