Influence of Secretio Bufonis Injection on Mean Survival Time and Carcinostatic Activities in Mice Bearing Intraperitoneal H22 Tumor
- VernacularTitle:蟾酥注射液对H22腹水型肝癌的抑制作用及对荷瘤小鼠生存周期的影响
- Author:
Jun JIN
;
Mingxi ZHANG
;
Ludi FU
- Publication Type:Journal Article
- Keywords:
Secretio bufonis injection;
bearing intraperitoneal H22 tumor;
survival time;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of Secretio bufonis injection on the carcinostatic activities in mice bearing intraperitoneal H22 tumor. Methods Secretio bufonis injection (1.5 mL) was injected into the abdomind cavity of mice once 5 d for 3 times. Cyclophosphamide (0.5 mg/0.5 mL) was injected into other groups. NS (0.5 mL) was injected into control groups. Each group were 20 mice. TNF and survival time of mice were observed. Results Mean survival times of mice bearing intraperitoneal H22 tumor were (28.2?5.8)d for Secretio bufonis group,(27.9?9.7)d for Cyclophosphamide group,(20.7?4.2)d for control group. The content of TNF in mice bearing intraperitoneal H22 tumor were 2.53?0.14 for Secretio bufonis group,3.02?0.14 for Cyclophosphamide group,3.32?0.2 for control group. The survival times of mice bearing intraperitoneal H22 tumor were prolonged in the groups of Secretio bufonis (P
