Effect and mechanism of Gujingdan on acute renal injury induced by gentamicin
- VernacularTitle:固精丹对庆大霉素急性肾损伤的防治作用及机制研究
- Author:
Xiulan CHEN
;
Li GUO
;
Yuyang ZHANG
;
Minwei WANG
- Publication Type:Journal Article
- Keywords:
Gujingdan;
Gentamicin;
renal injury;
rat
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the protective effect and mechanism of Gujingdan(Radix Astragali,Fructus Alpiniae oxyphyllae,Radix et Rhizoma Salviae miltiorrhizae,Herba Epimedii,Semen Euryales,etc.) on the acute renal injury caused by Gentamicin in rats.METHODS:90 rats were randomly divided into normal control group,pathologic model group,preventive group which included high,middle and low dosages of Gujingdan(4 g/kg,2 g/kg,1 g/kg) and positive control group which was treated with Shenkangning(2 g/kg) and treated group which included the same groups as the preventive group.The preventive groups were respectively given Gujingdan and Shenkangning for two weeks and ahead one week.On the seventh day,except the normal group the others were continuously injected gentamicin by abdominal cavity(100 mg/kg/day) seven days.At the same time,the treated group were given Gujingdan and Shenkangning by ig for seven days.When the experiment was over,the content of ?-N-acetyglocosamidase(NAG),serum creatinine(SCR) and blood urea nitrogen(BUN) were examined,and the renal histological changes were observed.RESULTS:NAG,BUN,SCR of the groups which were treated with Gujingdan were remarkly lower than that of the pathologic model group;SOD、ATP were higher and MDA was lower than that of the model group.Histological changes showed that renal tubular epithelial cells of the groups treated with Gujingdan were similar to the changes of normal group and much better than that of positive group and pathologic model group.CONCLUSION:Gujingdan has the protective effect on acute renal injury caused by Gentamicin.The mechanism may be that Gujingdan has the function of inhibiting oxidation,protecting and stabilizing cell membrane.
