Protective Effects of ?-asarone on PC12 Cells Damage Induced by Glutamate
- VernacularTitle:?-细辛醚对谷氨酸所致PC12细胞损伤的保护作用
- Author:
Yizhi CHEN
;
Yongqi FANG
;
Yi LIANG
- Publication Type:Journal Article
- Keywords:
PC12 cells;
Glutamate;
Ca2+;
?-asarone
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of ?-asarone on PC12 cells damage induced by Glutamate. Method The effects of ?-asarone on PC12 cells after Glutamate intoxication on morphology, extent of damage, livability, intracellular calcium concentration and apoptosis ratio were observed. Result Morphological changes, LDH leakage and intracellular calcium concentration increasing, and cell survival decreasing were observed in PC12 cells exposured to Glutamate. 7.5, 15, 30 ?g/mL?-asarone can increase cell survival, decrease LDH leakage. 15, 30 ?g/mL ?-asarone can reduce intracellular calcium concentration and apoptosis ratio. Conclusion ?-asarone prevents the toxicity of Glutamate, and it maybe attribute to its effect of anticalcium.
