Effects of Tonifying Kidney-Yin on the Activities of Embryonic Stem Cell
- VernacularTitle:补肾阴对胚胎干细胞活动的影响
- Author:
Hongmei AN
;
Bing HU
;
Yunfeng SHI
- Publication Type:Journal Article
- Keywords:
Tonifying the kidney-yin;
Chiese herb;
embryo stem cell
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of tonifying kidney-yin on activities of embryo stem cell. Methods Embryonic stem cell line CRL-1825 was choosed as model cell in present study, and tonifying kidney-yin herb serum was added to CRL-1825 cell. The influence of tonifying kidney-yin on stem cell differentiation, cell cycle, apotosis and express of key genes were observed. Results Tonifying kidney-yin can inhibit stem cell differentiation and apotosis, promote stem cell proliferation and progression of cell cycle. In addition, tonifying kidney-yin can up-regulate Wnt, Oct4 gene expression, and down-regulation P16INK4a expression. Conclusions Tonifying kidney-yin can promote stem cell proliferation and maintain the state of stem cell.
