MODIFIED RECOMBINANT HUMAN aFGF PROTECTS TYROSINE HYDROXYLASE NEURONS IN SUBSTANTIA NIGRA OF PARKINSON DISEASE RATS FROM LOSS
- VernacularTitle:重组人改构体酸性成纤维细胞生长因子减少帕金森病大鼠黑质酪氨酸羟化酶免疫阳性神经元丢失
- Author:
Guoqing GUO
;
Chungou XIAO
;
Hui WANG
;
Weizai SHEN
;
Lin YUAN
;
Shizhen ZHONG
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Modified recombinant human acid fibroblast growth factor;
Tyrosine hydroxylase;
Substantia nigra;
Immunocytochemistry;
Rat
- From:
Acta Anatomica Sinica
1955;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of rotation behavior and tyrosine hydroxylase immunopositive neurons and investigate how Mrh-aFGF affects them in substantia nigra of Parkinson disease rats. Methods After building a rat model of Parkinson disease by injecting 6-OHDA into substantia nigra and ventral tegmental area,we used Mrh-aFGF to intervene rats by lateral ventricle injection to observe how behavior of rats induced by apomorphine and tyrosine hydroxylase immunopositive neurons in substantia nigra of rats changes,then quantitatively analyzed the change of tyrosine hydroxylase immunopositive neurons. Results Rotation behavior was not found in control group,otherwise,actuation time was shorted,time length was prolonged,and average velocity of rotation was accelerated in Parkinson disease rats(P
