Anticoagulant Activities of Phlorotannins from Sargassum thunbeergii Kuntze
- VernacularTitle:鼠尾藻多酚的抗凝血活性研究
- Author:
Jing LI
;
Yuxi WEI
;
Guicai DU
;
Yingfen HU
;
Li LI
- Publication Type:Journal Article
- Keywords:
Sargassum thunbeergii Kuntze;
Phlorotannins;
Anticoagulant activity
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anticoagulant activities of phlorotannins STP-1 and STP-2 from Sargassum thunbeergii Kuntze.Methods Coagulation time(CT)and bleeding time(BT)of mice were determined by in-vivo experiment to test the effect of phlorotannins by capillary method and cutting tail method respectively.Furthermore,activated partial thromboplastin time(APTT),prothrombin time(PT)and thrombin time(TT)were measured to evaluate the in-vitro anticoagulant activity of phlorotannins on New Zealand rabbits.Results Phlorotannins STP-1 had a significant effect on the prolongation of CT,BT,APTT,PT and TT,especially at the dosage of 1.0 mg/mL.Conclusion Phlorotannins STP-1 has both in-vivo and in-vitro anticoagulant activity.
