Effects of Qingjin Desheng Tablets on Telomerase and Protein Expressions of Apoptosis Relevant Genes in Human Lung Adenocarcinoma Cells
- VernacularTitle:清金得生片对人肺腺癌细胞端粒酶及凋亡相关基因蛋白表达的影响
- Author:
Linxiang CHEN
;
Daihan ZHOU
;
Xuexin CHEN
;
Yao CHEN
- Publication Type:Journal Article
- Keywords:
Qingjin Desheng Tablets;
Human lung adenocarcinoma cells;
Telomerase;
Bcl-2;
Bax;
Immunohistochemistry
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the molecular mechanism of Qingjin Desheng Tablets on inhibiting the growth of lung cancer cells and to supply experimental evidences for Chinese herbal medicine preventing and curing lung cancer in clinical application .Methods Immunohistochemistry staining was used to detect the activity of telomerase and the expression of bcl-2 and bax in human lung adenocarcinoma cells after treated with serum containing Qingjin Desheng Tablets.Results The activity of telomerase was inhibited significantly and the positive rate of bcl-2 protein reduced,and the positive rate of bax2 increased in human lung adenocarcinoma cells after 72 hour-treatment with the serum containing Qingjin Desheng Tablets.Conlusion Qingjin Desheng Tablets exert the anti-tumor action through inhibiting the activity of telomerace and modulating the expression of bcl-2 and bax protein.
