Bioavailability Comparison Between Andrographolide Oral Microemulsion and Andrographolide Pill in Rabbits
- VernacularTitle:穿心莲内酯口服微乳与穿心莲内酯片在家兔体内生物利用度的比较研究
- Author:
Hong DU
;
Xin NIU
;
Qianjin FENG
;
Minglei YE
- Publication Type:Journal Article
- Keywords:
Andrographolide oral microemulsion;
Andrographolide pill;
HPLC;
Bioavailability;
Pharmacokinetics
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the difference in bioavailability of microemulsion and pill by detecting the concentration of andrographolide in rabbit plasma.Methods RP-HPLC was used to detect the concentration of andrographolide in rabbits plasma at different time,and software 3p87 was used to analyze the pharmacokinetics parameter.Results The pharmacokinetics parameters of andrographolide oral microemulsion and andrographolide pill were as follows::AUC0-7=1 406.72 ? g? mL-1? min,Tpeak=27.08 min,Cmax=5.37 ? g/mL for microemulsion;AUC0-7=877.37 ? g? mL-1? min,Tpeak=61.04 min,Cmax=3.06 ? g/mL for the pill.Conclusion Oral microemulsion of andrographolide has a shorter peak time and higher biological availability than the pill.
