Inhibitory effects of honokoil on retinal neovascularization in mice
- VernacularTitle:和厚朴酚抑制视网膜新生血管形成的实验研究
- Author:
Xiaoxi LEI
;
Su LIU
;
Xiuju YAN
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
honokoil;
DR;
retinal NV;
angiongenesis inhibitors
- From:
Chinese Traditional Patent Medicine
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the inhibitory effect of honokiol on retinal NV. METHODS: Hyperoxia was induced in NV model in 60 mice.Twenty mice received an intraperitoneal injections of 100 mg/kg honokoil twice daily for 5 days as large-dosage group and 20 mice received 50 mg/kg as small one while 20 mice received BSS as control.The collagen IV immunohistochemical staining was used to observe retinal vessels.The effect was evaluated by counting the nuclei extending from retina to vitreous and expressions of VEGF and MMP-2. RESULTS: The reduced density of vessels in the treatment group were found in retinal.The number of nuclei was less in the treated groups,which in the lagre-dosage group was significantly less.The expressions to VEGF and MMP-2 were less in the treatment than in the control respectively.That in the large-dosage group was significantly less. CONCLUSION: Intraperitoneal injections of honokoil can effectively inhibit retinal NV,depending on dosage.
