Effects of Valsartan on cardiomyocyte apoptosis and ASK1 protein expression in pressure overload-induced cardiac hypertrophy in rats
- VernacularTitle:缬沙坦对超负荷大鼠心肌细胞凋亡、ASK1的影响
- Author:
Min QIU
- Publication Type:Journal Article
- Keywords:
Myocardial hypertrophy;
ASK1;
Apoptosis;
Angll;
Valsartan
- From:
Journal of Chongqing Medical University
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the effects of Valsartan on cardiomyocyte apoptosis and apoptosis signal-regulating kinase 1 (ASK1)-dependent signal pathway in cardiac pressure-overload hypertrophy.Methods:The hypertensive model was established by abdominal aortic constriction.24 wistar rats were randomized into three groups,banding group,banding and Valsartan admin- istration group,sham-operated group.Six weeks later,cardiomyocyte apoptosis was measured by TUNEL,ASKI protein expres- sion was measured by western blot and immunohistochemistry.Results:The left ventricular mass index,apoptosis index and ASKI protein content all significantly decreased in Valsartan group,as compared with banding group(P
