Effect of Kidney-nourishing,Toxicity-removing and Blood-activating Herbal Medicines on Parameters Associated with Mesenteric Proliferation in Lupus Nephritis
- VernacularTitle:滋肾解毒活血中药对狼疮性肾炎系膜增殖的影响
- Author:
Airong QI
;
Tiegang YI
;
Xueyao LIU
;
Qinguo HONG
- Publication Type:Journal Article
- Keywords:
NOURISHING KIDNEY,REMOVING TOXICITY AND ACTIVATING BLOOD;
LUPUS NEPHRITIS/TCM-WM therapy;
SICAOTANG DECOCTION/therapeutic use;
FIBRONECTIN;
GENE,BCL-2;
MESENTERIC PROLIFERATION
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the effect of Sicaotang Decoction which is mainly composed of kidney-nourishing,toxicity-removing and blood-activating herbal medicines on parameters associated with mesenteric proliferation,fibronectin(FN),and Bcl-2 gene expression in lupus nephritis(LN).【Methods】 Sixty LN patients were equally randomized into two groups.The two groups received treatment with hormones and cyclophosphamide,and group Areceived Sicaotang Decoction additionally.The changes of Bcl-2 and Fas expression in CD4+ and CD8+ of T lymphocyte subtypes,serum fibronectin(FN),serum and urine collagen Ⅳ(CⅣ) as well as score of blood stasis were observed.【Results】Sicaotang Decoction reduced the expression of Bcl-2 and Fas expression in CD4+ and CD8+,relieved the proliferation of mesenteric cells,and decreased Bcl-2 positive rate,serum FN level,serum and urine CⅣ levels and score of blood stasis(P
