Influence of ?-asaricin in Volatile Oil from Rhizoma Acori Tatarinowii on Bronchial Asthma
- VernacularTitle:石菖蒲挥发油?-细辛醚对支气管哮喘的影响
- Author:
Jianmin XU
- Publication Type:Journal Article
- Keywords:
?-ASARICIN/pharmacology;
BRONCHIAL ASTHMA/TCD therapy;
DISEASE MODELS,ANIMAL;
GUINEA PIGS
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
1999;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
【Objective】To observe the effect of ?-asaricin spray on guinea pigs bronchial asthma.【Methods】Thirty FMMU guinea pigs were equally randomized into three groups:A(treated with ?-asaricin spray),B(treated with aminophylline)and C(model).Ater 7-day treatment,the guinea pigs received nebulization of histamine and acetylcholine to induce asthma models.And the effect of ?-asaricin on asthmatic attack latency and fall latency in guinea pigs was observed.The isolated trachea was used to observe the effect of ?-asaricin on tension of isolated bronchial smooth muscle.Other 30 guinea pigs were also randomized into three groups.The guinea pigs were sensitized with 40?g/L ovalbumin and Al(OH)3 firstly,treated with nebulization therapy for 7 days,and then induced asthma by nebulization of ovalbumin to observe the effect on the degranulation of mastocytes in bronchus and lung tissue.【Results】?-asaricin prolonged asthma latency and fall latency,inhibited the degranulation of mastocytes induced by ovalbumin and Al(OH)3,and promoted the relaxation of bronchial smooth muscle induced by histamine and acetylcholine,the difference being significant(P
