Experimental study of inhibited cardiomyocyte apoptosis and improved cardiac function by simvastatin after myocardial infarction
- VernacularTitle:辛伐他汀抑制心肌梗死后心肌细胞凋亡及改善心功能的实验研究
- Author:
Qiang YE
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Myocardial infarction;
Apoptosis
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of simvastatin on cardiomyocyte apoptosis and cardiac dysfuction after myocardial infarction.Method:Simvastatin was administrated to the rats with myocardial infarction which was modeled by left anterior descending coronary artery ligation. After 7days, the apoptotic myocyte cells were quantified by TUNEL staining;left ventricular function index was measured by echocardiography and the level of serum lipid was measured by biochemical method.Results:Compared with infarction group, apoptotic myocyte cells in simvastatin group significantly decreased in infarction zone,border zone and non-infarction zone(P0.05).Conclusion:Simvastatin inhibits cardiomyocyte apoptosis and improves cardiac function after myocardial infarction.
