Clinical and pathological features of keratoacanthoma
- VernacularTitle:角化棘皮瘤的临床与病理分析
- Author:
Kui SHAN
- Publication Type:Journal Article
- Keywords:
Keratoacanthoma;
Clinical analysis;
Pathological feature;
p53;
bcl-2;
P-gp
- From:
Journal of Chongqing Medical University
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinical and pathological features,malignancy and prognosis of keratoacanthoma(KA).Methods: Eighteen patients with KA were collected, and their clinical features were analyzed with pathological aspects observed by immunohistochemical SP techniques.Results:The typical lesion of KA is a hemispheric,dome-shaped,skin-colored nodule in which there is a smooth crater filled with a central keratin plug.Histological examination showed a crater filled with eosinophilic keratin.A"lip"formed by invagination of epidermis surrounds the keratin-filled crater.Wide excision of the lesions is the first choice for the treatment of KA. The expression levels of p53 was higher than controls(P
