Decrease in Plasma Adiponectin Concentrations in Patients with Vasospastic Angina.
10.4070/kcj.2006.36.4.255
- Author:
Soon Jun HONG
1
;
Chang Gyu PARK
;
Hong Seog SEO
;
Seung Woon RHA
;
Jin Won KIM
;
Dong Joo OH
;
Jung Ah KWON
;
Kap No LEE
;
Yang Soo JANG
;
Young Moo RO
Author Information
1. Department of Cardiology, Cardiovascular Center, Korea University, Seoul, Korea. parkcg@kumc.or.kr
- Publication Type:Original Article
- Keywords:
Adiponectin;
Coronary artery vasospasm;
Acetylcholine
- MeSH:
Acetylcholine;
Acute Coronary Syndrome;
Adiponectin*;
Angina Pectoris;
Angina, Stable;
Angina, Unstable;
Atherosclerosis;
Chest Pain;
Coronary Angiography;
Coronary Artery Disease;
Coronary Vasospasm;
Coronary Vessels;
Female;
Humans;
Insulin Resistance;
Macrophages;
Multivariate Analysis;
Myocardial Infarction;
Plasma*;
Smoke;
Smoking
- From:Korean Circulation Journal
2006;36(4):255-260
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. SUBJECTS AND METHODS: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. RESULTS: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6+/-5.4 vs. 5.2+/-4.0 vs. 9.0+/-6.2 microgram/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. CONCLUSION: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.
