Analysis of lignans in the serum of rats after oral administration of Compound Wurenchun Capsules by UPLC-MS/MS
- VernacularTitle:复方五仁醇胶囊含药血清中木脂素类成分的UPLC-MS/MS分析
- Author:
Zhihua DOU
;
Anwei DING
;
Wenzheng JU
;
Lin LUO
- Publication Type:Journal Article
- Keywords:
Compound Wurenchun Capsules;
serum containing drug;
lignans;
Ultra performance Liquid Chromatography-Tandem Mass (UPLC-Mass/Mass)
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To illuminate the therapeutic basis of Compound Wurenchun Capsules in combination with serum pharmacology,the lignans of this preparation migrating to blood of rats after oral administration having been accomplished. METHODS: By UPLC-MS/MS method, lignans migrating to blood were affirmed by comparing the extracted ion chromatography (EIC) of the serum containing drug with the ones of Compound Wurenchun Capsules, the control serum and control articles, correlated ion peak in mass-spectrogram were analyzed at the same time. RESULTS: Five lignans migrating to blood have been found, they are schisandrin, schisandrol B, schisantherin, deoxyschizandrin and schisandrin B. CONCLUSION: Five lignans above mentioned are likely the effective substances of Compound Wurenchun Capsules in human body. More study by means of combining with serum pharmacology will illuminate the therapeutic basis of this preparation.
