Hepatic intraarterial~(131)Ⅰ-HAb18F(ab')_2 radioimmunotherapy on PLC with different types of blood supply through DSA
- VernacularTitle:肝癌DSA血供类型与经肝动脉灌注~(131)Ⅰ-HAb18F(ab')_2治疗后瘤体大小变化的关系探讨
- Author:
Shaoping WU
;
Wusheng LU
;
Dawei XU
;
Zhiyong ZHENG
- Publication Type:Journal Article
- Keywords:
Primary liver cancer;
DSA;
131Ⅰ-HAb18;
Radioimmunotherapy;
Hepatic artery
- From:
Journal of Interventional Radiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the possible different effects on primary liver cancer of various types of blood supply demonstrated by DSA via hepatic artery radioimmunotherapy with 131Ⅰ-HAb18F(ab')2.Methods Under thyroid protection and negative dermal sensitivity test,46 times of intraarterial injection with a 0.75 mCi/kg dose of 131Ⅰ labeled murine HCC monoclonal antibody fragment [HAb18F(ab')2] were performed in 30 patients of PLC using the Seldinger technique.The shrinkage rates of tumor volume were analyzed according to hyper,moderate and hypo vascular three types provided by DSA.Results The volume shrinkage rates of hyper and moderate vascular HCC were 60% and 37.5% respectively,while that of 2 cases of hypovascular HCC showed significantly reduction.Conclusion 131Ⅰ-HAb18F(ab')2 internal radioimmunotherapy prossesses certain signification volume shrinkage efficacy on different blood supplies provided by DSA.(J Intervent Radiol,2007,16:243-245)
