Effect of Pingxian Powder on N-methyl-D-aspartate Recptor and ?-aminobutyric acid-A Receptor in the Temporal Cortex of Pentylenetetrazole Kindling Epileptic Rat Model
- VernacularTitle:平痫冲剂对戊四唑致痫大鼠颞叶谷氨酸受体和?-氨基丁酸受体的影响
- Author:
Shiqing ZHANG
;
Rong TIAN
;
Zhenggang SHI
- Publication Type:Journal Article
- Keywords:
epilepsy;
Pingxian powder;
Pentylenetetrazole (PTZ) kindling epileptic rat model;
receptor
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible antiepileptic mechanism of Pingxian Powder. Methods In the experiment,Pentylenetetrazole (PTZ) was injected into abdomen of rat to make epileptic kindling model. The total number,percentage of positive area and integral optical density of N-methyl-D-aspartate receptor1 (NMDAR1) and ?-aminobutyric acid-A receptor (GABA-AR?1) of immunoreactive cells in the temporal cortex were studied by the immunohistochemical method and image analyzing system. Results The total number,percentage of positive area and integral optical density of NMDAR1 of immunoreactive cells in the temporal cortex of model group were more than normal group (P
