Diterpenoids possessed immunosuppressive activity from Tripterygium hypoglaucum
- VernacularTitle:昆明山海棠中具有免疫抑制活性的二萜化合物
- Author:
Yanwen ZHANG
;
Yunshuang FAN
;
Xiaodong WANG
;
Wenyuan GAO
;
Hongquan DUAN
- Publication Type:Journal Article
- Keywords:
Tripterygium hypoglaucum (Level.) Hutch;
xylem;
diterpenoids;
immunosuppressive activity
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diterpenoids possessed immunosuppressive activity from Tripterygium hypoglaucum. Methods The chemical constituents were isolated from the CHCl3 extracts of T. hypoglaucum by repeated column chromatography, including silica gel, Sephadex LH-20, and preparative HPLC. Their structures were elucidated on the basis of spectroscopic studies. The immunosuppressive activity of these compounds was tested using the lymphocyte transformation test. Results Compounds Ⅰ-Ⅵ were identified as triptobenzene H (Ⅰ), triptoquinone A (Ⅱ), triptoquinone B (Ⅲ), triptoquinone H (Ⅳ), triptonediol (Ⅴ), triptonoterpene (Ⅵ). Conclusion Compound Ⅰ-Ⅲ are isolated from this medicinal plant for the first time and all the compounds show the significant immunosuppressive activity.
