Effect of Hypoxia-inducible factor-1 alpha on the radiosensitivity of rat cervical carcinoma
- VernacularTitle:低氧诱导因子1?对小鼠宫颈癌放射敏感性的影响
- Author:
Fangxin LIU
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor-1?(HIF-1?);
Radiosensitivity;
Cervical carcinoma
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of Hypoxia-inducible factor-1 alpha(HIF-1?)on the radiosensitivity of rat cervical carcinoma and discuss the possible mechanism.Methods:The transplantation tumor model of cervical carcinoma was established. 77 rats were randomly divided into five groups:control group,the large fraction irradiation group,the small fraction irradiation group,the large fraction irradiation combining HBO group and the low dose irradiation combining HBO group.Expressions of HIF-1? and bcl-2 in transplantation tumor after treatment were detected by immunohistochemical staining,and the tumor inhibitory rate by the change of tumor volume.The correlation between expressions of HIF-1 ? and bcl-2(and tumor inhibitory rate)was also observed.Results:Expression of HIF-1 ? and carcinoma growth inhibitory rate showed a reverse correlation(r=-5.147,P
