Effect of Nimodipine on the expression of synaptic protein and mRNA in diabetic rat hippocampus
- VernacularTitle:尼莫地平对糖尿病大鼠海马突触素蛋白和mRNA表达的影响
- Author:
Yuan GAO
- Publication Type:Journal Article
- Keywords:
Nimodipine;
Diabetes;
Cognition;
Synaptophysin
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of Nimodipine on synaptophysin in diabetic rat.Methods:38 Wistar rats were divided into the normal control group, diabetic model group, the Nimodipine treatment group randomly. Streptozotocin-diabetic rat model was established. The diabetic rats were treated with Nimodipine for 12 weeks. Then, the learning and memory abilities of rats were tested with the Morris water maze.The mRNA and protein level of synaptophysin in hippocampus were detected by RT-PCR and immunohistochemical method. Results:Compared with diabetic model group, the Nimodipine treatment group showed a significant decrease in the mean time of escape latencies(P
