Effects of Ketangte 2 on Experimental Diabetes in Mice
- VernacularTitle:克糖特2号对实验性糖尿病小鼠的药效学研究
- Author:
Yulan LUO
;
Jiejin MA
;
Renbin HUANG
;
Hang DENG
- Publication Type:Journal Article
- Keywords:
Kefante 2;
Carambola leaf;
Diabetes mellitus;
Blood sugar;
Pharmacology
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Ketangte 2 on experimental diabetes in mice.Methods Adrenalin and streptozocin(STZ) were used to induce hyperglycemia mice model and diabetic mice model respectively.The mice were divided into five groups randomly:model group,glibenclamide control group,high-,middium-,low-dosage Ketangte 2 groups.The administration lasted consecutive 15 days.The blank control group and model group were treated with the same volume of saline.After treatment,the levels of blood sugar were measured in hyperglycemia mice induced by adrenalin,and the fasting blood-glucose,2-hour blood-glucose,insulin levels in diabetic mice induced by STZ were determined.Meanwhile the histopathological changes of pancreas were observed under light microscope.Results For STZ-induced diabetic mice,the hypoglycemic effect of Ketangte 2 was obvious(P
