Comparison of the release and percutaneous penetration in vitro between psoralen ointment and gel
- VernacularTitle:补骨脂素乳膏与凝胶体外释放与透皮吸收的比较研究
- Author:
Fangfang HUANG
;
Depo YANG
;
Shuming LIANG
- Publication Type:Journal Article
- Keywords:
psoralen;
ointment;
gel;
in vitro release;
percutaneous penetration
- From:
Chinese Traditional Patent Medicine
1992;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the release and percutaneous penetration in vitro among 2 kinds of the psoralen ointments and its gel. METHODS: Dissolution tester and Franz diffusion cells were adopted as the release and percutaneous penetration in vitro, and HPLC was used to measure the amount of psoralen in the releasing solution, receiving solution and the skin. RESULTS: The release and percutaneous penetration of psoralen from the 3 kinds of preparation conformed to the zero kinetic equation. The steady-state penetration rate of psoralen in the gel was higher than that of the ointment, and there was no significant difference between 2 kinds of ointments. CONCLUSION: Gel is a better choice for percutaneous penetration of psoralen.
