Effect of Salvia Miltiorrhiza on Aquaporin-1 Expression in Rats Model of Lipopolysaccharideinduced Acute Lung Injury
- VernacularTitle:丹参对内毒素致急性肺损伤大鼠肺水通道蛋白-1的调节效应
- Author:
Min LI
;
Feng LI
;
Bo HU
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza;
acute lung injury;
lipopolysaccharide;
aquaporin-1;
hemorheology
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of SM on aquaporin-1(AQP-1) expression in rats with acute lung injury(ALI) induced by lipopolysaccharide(LPS). Method 48 SD rats were randomly divided into normal group,ALI 7-day group,ALI 8-hour group,SM prevention group,SM 7-day treatment group,and SM 8-hour treatment group,8 rats per group. At 8 hours and 7 days after treatment,lung wet to dry weight ratio,lung pathology,electron microscope,AQP-1 immunohistochemistry,and AQP-1 Western blotting were performed. The situation of hemorheology and serum level of PaO2 and Endothelin-1(ET-1) were also detected. Results The model group rats all appeared ALI symptom. Compared with the 7-day ALI group,the degree of lung edema statement alleviated in SM 7-day treatment group. But the expression difference of AQP-1 was not significant between the two groups(P
