Study of Panax Notoginseng F.H.Chen and Cordyceps sinensis Sacc. Powder Inhibiting Mouse Mammary Adenocarcinoma and Tumor Angiogenesis
- VernacularTitle:三七虫草混合粉抗小鼠乳腺肿瘤及其新生血管效应研究
- Author:
Yanming ZHANG
;
Xiaoming LI
;
Xinyi CHEN
- Publication Type:Journal Article
- Keywords:
Panax notoginseng F.H.Chen and Cordyceps sinensis Sacc. powder;
mouse mammary adenocarcinoma(EMT6);
MVD;
VEGF;
TIMP-2
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe inhibition rate of mouse mammary adenocarcinoma(EMT6) and inhibition effect on tumor angiogenesis of Panax notoginseng F.H. Chen and Cordyecps sinensis Sacc. powder. Methods BALB/C mice as bearing cancer animals with subcultured mouse-transplantable EMT6 cell train had accepted intervention treatment by Panax notoginseng F.H. Chen and Cordyceps sinensis Sacc. powder. In this way,inhibition rate of the mouse-transplanted EMT6 by the powder was recorded and the expression of microvessel density(MVD),vascular endothelial growth factor(VEGF) and tissue inhibitor of metalloproteinase-2(TIMP-2) in the tumor tissue after paraffin imbedding and section were detected through immunohistochemistry technique. Results The tumor inhibition rates of two designed dose groups were separately 48.95% and 37.64%. MVD and VEGF expressions of tumor tissue in the two group were significantly suppressed while the TIMP-2 expression increased. Conclusions Panax notoginseng F.H.Chen and Cordyceps sinensis Sacc. powder can restrain the growth of EMT6,and the pathway of this function is likely related to inhibiting tumor angiogenesis.
