Absorption of curcumin microemulsion in vivo
- VernacularTitle:姜黄素微乳的体内吸收研究
- Author:
Jing CUI
;
Guangxi ZHAI
;
Yu ZHAO
;
Hongxiang LOU
- Publication Type:Journal Article
- Keywords:
curcumin;
self-microemulsion;
in situ absorption in intestnum tenue
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the curcumin self-microemulsion, observe the morphology and size diameter distribution of the microemulsion, and compare the absorption kinetics of curcumin microemulsion and micelle. To investigate the best absorption segment of curcumin microemulsion in intestnum tenue and the absorption of curcumin self-microemulsion in mouse gastrointestinal tract. MethodsThe intestine in rats was cannulated in situ recirculation. The absorption of curcumin microemulsion was calculated by its decrement in intestnum tenue.The inabsorbable curcumin in all content together with feces in mouse gastrointestinal tract was obtained and used to calculate the absorption rate of curcumin. ResultsThe curcumin microemulsion presented as small spherical drops or something similar under transmission electron microscope (TEM) with the average diameter of about 21.6 nm. The absorption constants of curcumin microemulsion and micelle was 0.042 5 and 0.019 5 /h , the main segments of curcumin microemulsion absorption were intestinum duodenum and intestinum jejunum. The absorption rate of curcumin self-microemulsion was 2.5 times as much as curcumin. ConclusionThe curcumin self-microemulsion could improve the absorption of curcumin in vivo in animal evidently.
