Effect of radix of Salvia miltiorrhiza fraction on conditioned place preference in mice induced by morphine
- VernacularTitle:丹参有效部位对吗啡依赖性小鼠位置偏爱效应的影响
- Author:
Fang HE
;
Juan YU
;
Chonghong CHEN
- Publication Type:Journal Article
- Keywords:
the radix of Salvia miltiorrhiza Bunge;
morphine;
conditioned place preference (CPP);
cryptotanshinone
- From:
Chinese Traditional and Herbal Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of lipid soluble fraction in the radix of Salvia miltiorrhiza (FSM) on conditioned place preference (CPP) in mice induced by morphine and preliminarily identify the fraction in the radix of S. miltiorrhiza. MethodsMorphine or NS was sc injected every other day to induce the obvious CPP in mice for 6 d. Before 30 min of sc injecting morphine, mice were ip administered different doses of lipid soluble fraction in the radix of S. miltiorrhiza. RP-HPLC method was used to identify the major component in the lipid soluble fraction in the radix of S. miltiorrhiza. ResultsThe staying time in morphine-paired white compartment was significantly prolonged. After treatment with lipid soluble fraction in the radix of S. miltiorrhiza (40 mg/kg, ip), the staying time in morphine-paired white compartment was significantly shortened (P
