Insulin resistance and ?-cell function of subjects with Metabolic Syndrome
- VernacularTitle:代谢综合征人群的胰岛素抵抗及胰岛?细胞功能
- Author:
Lilin GONG
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Insulin resistance;
Insulin ?-cell function
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To calculate prevalence of insulin resistance(IR) among individuals who met the criteria for Metabolic Syndrome(MS) of International Diabetes Federation(IDF) definition and to investigate clinical characteristics and ?-cell function in patients of MS with or without IR.Methods:Random stratified sampling method was applied to the cross-sectional epidemiology survey on subjects aged 20years and over in Chongqing district.For all subjects,somatometry parameters were tested,75gram oral glucose tolerance tests were conducted,and some other parameters were also detected,like blood glucose,lipid-profile and insulin.Data of 2323 subjects with complete laboratory data were gathered for analysis.Homeostasis model assessment of insulin resistance(Homa-IR) was used to estimate insulin resistance,and Homa-? and disposition index(DI) to evaluate ?-cell function.Results:(1)MS was presented in 482 individuals(20.77%),diagnosed according to the definition proposed by IDF in 2005.In those subjects with MS,there were 290 individuals(60.17%) with IR and 192 individuals(39.83%) without IR.(2)The MS without IR group had lower body mass index,fasting and 2h post-load plasma glucose,diastolic blood pressure and triglyceride than the MS with IR group,and the difference was significant(P
