Mechanisms of angiogenesis,invasion and metastasis inhibited by arsenic trioxide(As_2O_3) in human renal cell carcinoma 786-0 cells
- VernacularTitle:As_2O_3抑制人肾癌786-0细胞血管生成及浸润转移机制的初步研究
- Author:
Delin WANG
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Renal cell carcinoma;
786-0 cells;
Angiogenesis;
Metastasis
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mechanisms of angiogenesis,invasion and metastasis inhibited by arsenic trioxide(As2O3)in human renal cell carcinoma 786-0 cells.Methods:The changes of VEGF,nm23,MMP-9,and TIMP-1 protein expression were studied by immunocytochemistry,and TGF-?1,T?R-I and T?R-II mRNA were analysed by reverse transcription polymerase chain reaction in 786-0 cells treated with As2O3.Results:2?mol/L As2O3 effectively inhibited the protein expression of VEGF and MMP-9 in 786-0 cells(P
