Significance of Leptin in assessment of insulin-sensitizing agent therapy for PCOS and correlation analysis
- VernacularTitle:瘦素在胰岛素增敏剂治疗多囊卵巢综合征中的相关研究
- Author:
Lianlian WANG
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Leptin
- From:
Journal of Chongqing Medical University
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the indicative value of the serum leptin level in obesity and non-obesity PCOS patients treated with insulin-sensitizing agent rosiglitazone.Methods:73 PCOS patients were divided into obesity(43)and non-obesity group(30).The changes of the serum leptin level and the relevant indexes were observed before and after treament with rosiglitazone.Results:the leptin level of PCOS groups was higher than that in control and the level in obesity PCOS patients was higher than that in non-obesity PCOS patients both before and after treatment.After treatment,the leptin levels in both PCOS groups were all significantly decreased,greater decrease in obesity group.Correlation:analysis revealed that the leptin level had positive correlation with BMI,FINS and LH,but negative correlation with the HGCT.Conclusion serum leptin level has some indicative value in the assessment of insulin-sensitizing agent in treating PCOS.
