Preventive Effect of Xianlingqianggukoufuye on Postmenopausal Osteoporosis in Ovariectomized Rats
- VernacularTitle:仙灵强骨口服液对去势老龄大鼠骨质疏松症的预防作用
- Author:
Haiying TANG
;
Dongchun WANG
;
Aimin TAN
- Publication Type:Journal Article
- Keywords:
Xianlingqianggukoufuye;
postmenopausal osteoporosis;
ovariectomy;
rat
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Xianlingqianggukoufuye (XLQGKFY) on postmenopausal osteoporosis in ovariectomized female rats. Method 60 female Sprague-dawley rats in 7-month were used, 50 of them were ovariectomized and randomly divided into 5 groups:ovariectomized (OVX), OVX+ Nylestriol, OVX+XLQGKFY (high dose, middle dose, low dose), the others were sham-operated group. Rats were treated with drugs starting at 3rd day after the operation for 90 days. Double in vivo fluorochrome labeling was administered to all rats. At the end-point of study, the blood was collected to detecte contents of ALP, StrACP in serum, the fourth lumar vertebra (LV4) and femur bone sections were cut and stained for bone histomorphometric analyses, biomechanical analyses and BMP analyses. Result XLQGKFY decreased greatly the StrACP content, increased bone stiffness, bone M-load, improved bone biomechanical property. Conclusion XLQGKFY has a good preventive effect on postmenopausal osteoporosis which provides for clinical use.
