Effect of Jinguishenqi Wan on TGF-?_1 Expression in Lung of Pulmonary Fibrosis Rats
- VernacularTitle:金匮肾气丸对肺纤维化大鼠肺组织转化生长因子?_1表达的影响
- Author:
Jianping SONG
;
Wei LI
;
Fangzhou LIU
- Publication Type:Journal Article
- Keywords:
pulmonary fibrosis;
transforming growth factor-?_1;
Jinkuishenqi wan
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and mechanism of Jinkuishenqi wan (JGSQ) on pulmonary fibrosis. Methods Pulmonary fibrosis was induced by bleomycinA5 in SD rats. Rats in treatment group were killed after being treated by JGSQ daily for 28 days. The lungs of all rats were harvested for histopathological studies. The contents of transforming growth factor-?_1 (TGF-?_1) in lungs were measured and compared. Results The contents of TGF-?_1 in lungs increased significantly in model group as compared with normal group and treatment group (P
