Correlation Between in vitro Chemosensitivity of Antineoplastic Drugs and its Clinical Response and Prognosis in Human Colorectal Cancers
- VernacularTitle:抗肿瘤药体外药敏与大肠癌疗效和预后的相关性
- Author:
Xiaobo ZHAI
;
Aiguo LU
;
Siwei BAO
;
Zhigao HE
- Publication Type:Journal Article
- Keywords:
Fluorouracil;
Mitomycin;
Colorectal cancer;
In vitro chemosensilivity;
MTT;
Chemotherapeulic results;
Cox model
- From:
Chinese Journal of Pharmacoepidemiology
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation between in vitro chemosensitivity of Fluorouraci(5-Fu) + Mitomycia (MMC) and its clinical response and prognosis in human colorectal cancers. Method:The chemosensitivity of 5-Fu + MMC was tested in 169 Dukes B and C colorectal cancers with the MTT method,and the progression-free internal and prognosis in 4 years following the surgery were observed. Result:Based on the in vitro chemosensitivity of 5-Fu + MMC, 100 patients were divided into an antagonistic group(28 patients) in which their relapse rates were 57. 1% and a synergistic-additive group(72 patients) in which their relapse rates were 22.2% (P
