EXPRESSION OF VEGF-C AND VEGFR-3 IN RAT COLORECTAL CANCER INDUCED BY MNNG
- VernacularTitle:血管内皮生长因子C及其受体在MNNG诱发的大鼠大肠癌细胞及淋巴管的表达
- Author:
Shucai YANG
;
Jing MA
;
Baoquan LIU
;
Linghua ZHAO
;
Yafang ZHANG
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor-C;
Vascular endothelial growth factor receptor-3;
Lymphatic vessels;
Colorectal neoplasms;
Immunohistochemistry;
Rat
- From:
Acta Anatomica Sinica
1953;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial growth factor C(VEGF-C) and vascular endothelial growth factor receptor-3(VEGFR-3) in rat colorectal cancer,and to provide an experimental material for the role of VEGF-C and its receptor VEGFR-3 in cancer progression and metastasis via lymphatics. Methods The expressions of VEGF-C and its receptor VEGFR-3 in colorectal cancer induced by MNNG were observed by immunohistochemistry staining. Results There was no expression of VEGF-C in normal colorectal tissues,but VEGFR-3 expressed in the lymphatic endothelium.The protein of VEGF-C mainly expressed in the cancer cells and the positive rates were 75% and 100% respectively in the early and the mid-terminal stages of cancer.The positive expression of VEGF-C in the early stage of cancer was higher than that in mid-terminal stage(P
