Expression and Significance of macrophage migration inhibitory factor mRNA in esophagus squamous cell carcinoma
- VernacularTitle:食管鳞癌组织中MIFmRNA的表达及其意义
- Author:
Jinsong ZHAO
- Publication Type:Journal Article
- Keywords:
Macrophage migration inhibitory factor;
Reverse transcription-polymerase chain reaction(RT-PCR);
Esophageal squamous cell carcinoma
- From:
Journal of Chongqing Medical University
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mRNA expression of macrophage migration inhibitory factor(MIF)in esophageal squamous cell carcinoma and its relationship with the clinical pathologic characteristics of that carcinoma.Methods:The expressions of MIF mRNA in esophageal carcinoma tissues and normal esophageal tissues were detected by RT-PCR in eighty patients.Results:MIF mRNA expression rate in esophageal carcinoma was 85%(68/80),while in the normal esophageal tissues it was 15%(15/80).the difference was significant(P0.05).Conclusion:Increased MIFmRNA expression contributed to carcinogenesis of esophageal squamous cell carcinoma,which might provide a new way for early diagnosis and therapy of esophageal carcinoma.
