Establishment of Blood Stasis and Brain Ischemia Rats Model
- VernacularTitle:大鼠血瘀合并脑缺血模型的建立
- Author:
Mingsan MIAO
;
Zaixing CHENG
;
Yanbing ZAI
;
Yulin ZHANG
;
Yamin LIU
- Publication Type:Journal Article
- Keywords:
Blood stasis;
Brain ischemia;
Disease model,animal
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the establishment method of brain ischemia model with blood stasis. Methods The rat models of blood stasis were established by intramuscular injection of dexamethasone 0.2 mg?kg-1?d-1 inside the thigh for successive 10 d. When the blood stasis models were successfully established, the rats were anaesthetized and common carotid arteries in both sides were separated and ligated to make brain ischemia model. Meanwhile the blank control group and Sham-operation to one of the model groups were conducted. Results Compared with the blank control group, the level of whole blood viscosity were obviously increased and TT、PT、APTT markedly decreased in the operation group and pseudo-operation group. Compared with the blank control group and the operation group, the changes of ATP activity,the LD ,LDH ,NO,NOS, SOD,MDA, Glu, T-AA, ET and CGRP levels were significant in the pseudo operation group(P
