Protective Effects of Ginseng-monkshood Extract Injection on Rats'Isolated Heart Suffered from Ischemia-Reperfusion
- VernacularTitle:参附注射液对大鼠离体心脏缺血再灌注损伤的保护作用
- Author:
Fang ZHAO
;
Li XU
;
Li XU
- Publication Type:Journal Article
- Keywords:
Ginseng-monkshood extract;
Isolated heart reperfusion;
Myocardial enzyme;
Rat
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the cardioprotective effect of ginseng-monkshood extract injection on ischemia-reperfusion injury in rats'isolated working hearts.Methods The heart models of ischemia-reperfusion injury were built by Langendorff isolated heart perfusion technology.The different concentrations of nitrogen saturated Ginseng-monkshood extract injection were used for infusion,and the indexes of heart rate,coronary flow and myocardial enzymes were observed in reperfusion 20 min and 40 min.Results Infusion of ginseng-monkshood extract injection can improved heart rate and flux of coronary artery and inhibit the leak of lactic dehydrogenase and creatine kinase during ischemia reperfusion.Conclusions Ginseng-monkshood extract injection has obviously protective effect on myocardial ischemia reperfusion injury.
