Improvement Effect of Ginsenoside Re on Learning and Memory Abilities of Natural Apolexis Rats and Its Mechanisms
- VernacularTitle:人参皂苷Re促进自然衰老大鼠学习记忆作用及其机理的研究
- Author:
Ying ZHAO
;
Jinping LIU
;
Dan LU
;
Yan ZHAO
;
Pingya LI
- Publication Type:Journal Article
- Keywords:
Ginsenoside Re;
Learning and memory;
Dentate gyrus;
Long-term potentiation
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influences of ginsenoside Re on learning and memory abilities of natural apolexis rats and to probe its preliminary mechanism.Method Water maze test for old rats was used to observe the effect of ginsenoside Re on learning and memory,and electrophysiological technique to record the long-term potentiation(LTP)in basic synaptic transmission of the dentate gyrus in anesthetized rats.Results Ginsenoside Re can markedly counteract memory acquisition impairment in natural apolexis rats,and enhance the synaptic transmission in the dentate gyrus and form the LTP consequence.Conclusion Ginsenoside Re can improve the learning and memory obstacle in rats,the mechanism may correlate with its enhancing the basic synaptic transmission and promoting the magnitude of LTP of the dentate gyrus.
