The Influence of Invigorating Spleen and Restoring Virility to on the Ability of Learing and Memory and SP, VIP Level in Brain
- VernacularTitle:健脾与补肾对脾虚模型大鼠学习记忆及脑内P物质、血管活性肠肽的影响
- Author:
Huinan QIAN
;
Hong XU
;
Libo SHEN
- Publication Type:Journal Article
- Keywords:
model of insufficiency Spleen;
learning and memory;
SP;
VIP
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To inquire into the changes of learning and memory ability and the level of SP, VIP in the brain of the model of Spleen insufficiency. To observe the influence invigorating spleen and restoring virility on above changes. Methods Establishing the spleen insufficiency model of rat by adopting bitter decline diarrhea, wild eating and overworking, to examine influence of invigorating spleen and restoring virility on the ability of learning and memory with the change of SP and VIP in the brain. Results In the period of study and remember of the water maze experiment, the swim whole distance time was long and mistake number was many in the model group; the swim whole distance time was short and the mistake number was little in the group of invigorating the Spleen and restoring virility. In the period of study and remember of the diving platform experiment, the mistake number of times is more and the incubation period was short in the model group; the mistake number was less and the incubation period was long in Spleen invigrating group. At the period of remember mistake number was more. In the model group, the immunoreaction masculine substance of SP level decrease obviously in the hypothalamus ventral kernel, the hippocampi CA1 area and forehand cortex; on above mentioned parts, the group of invigorating spleen and restoring virility increases distinctly, in the group of restoring virility increases distinctly in the hippocampi CA 1 area and forehead cortex, but decreased in hypothalamus ventral kernel. In the model group, the immunoreaction masculine substance of VIP level decreased obviously;in the hippocampi CA1 area and cortex;on above mentioned parts, the groups of invigorating spleen and restoring virility increases obviously. Conclusion In the model group, the ability of learing and memory with SP and VIP level in the brain changed. Invigorating spleen and restoring virility can improve above changes remarkably.
