Uniform design method for optimizing proportion of transdermal penetration enhancers of ligustrazine hydrochloride
- VernacularTitle:均匀设计法筛选盐酸川芎嗪促透剂组方的最佳配比
- Author:
Ruitao ZHANG
;
Hui WANG
;
Li CHEN
- Publication Type:Journal Article
- Keywords:
ligustrazine hydrochloride;
transdermal absorption;
synthetic borneol;
menthol;
Azone;
uniform design
- From:
Chinese Traditional and Herbal Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the proportion of three transdermal penetration enhancers on transdermal absorption of ligustrazine hydrochloride.Methods Permeation tests in vitro through BALB/c nude mouse skin in two compartment diffusion cells were performed to study the effect of synthetic borneol,menthol,and Azone on trandermal absorption of ligustrazine hydrochloride by changing their concentrations,and uniform design method was used to determine the penetration coefficient of ligustrazine hydrochloride and optimize the proportion of three transdermal penetration enhancers.ResultsThe optimal proportion and contents of synthetic borneol,menthol,and Azone were 1.5%∶1.5%∶1.5%(15 mg/mL∶15 mg/mL∶15 mg/mL),the real penetration coefficient of ligustrazine hydrochloride was 69.575 ?g/(h?cm2),while the theoretical penetration coefficient was 69.749 ?g/(h?cm2).Conclusion Uniform design method is an effective way to optimize the proportion of three transdermal penetration enhancers on trandermal absorption of ligustrazine hydrochloride.
