Effect of Ma Xing Shi Gan Decoction on Metabolism of Oxygen Free Radicals in Mice with Bronchial Asthma
- VernacularTitle:麻杏石甘汤对哮喘模型小鼠氧自由基代谢的影响
- Author:
Tongming LI
;
Guixiang WANG
;
Shijian QUAN
;
Jie GAO
;
Peijian WANG
- Publication Type:Journal Article
- Keywords:
MA XING SHI GAN DECOCTION/pharmacology;
ASTHMA/TCD therapy;
FREE RADICALS;
DISEASE MODELS,ANIMAL;
MICE
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To observe the effect of Ma Xing Shi Gan Decoction(MXSGD)on metabolism of oxygen free radicals in mice with bronchial asthma.【Methods】Forty BALB/c mice were randomized into 4 groups:normal group,model group,low-dose MXSGD group(20?g?kg~(-1)?d~(-1))and high-dose MXSGD group (80?g?kg~(-1)?d~(-1)).Except the normal group,the mice in other 3 groups received sensitization by intraperitoneal injection of ovalbumin(OVA)and challenge by inhalation of OVA to induce bronchial asthma.Meanwhile,MXSGD groups were given the corresponding doses according to the experimental design by gastric gavage,and normal group and model group received the same volume of normal saline for 27 days.Twelve-four hours after last challenge,blood sample was taken and homogenate of lung tissue was prepared for the detection of superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-Px)contents in the plasma and the lung tissue.【Results】High-and low-dose MXSGD increased SOD and GSH-Px contents and decrease MDA content in the lung tissue and plasma(P
