Establishment of adriamycin-induced dilated cardiomyopathy model in rabbits
- VernacularTitle:阿霉素诱导兔扩张型心肌病模型的建立
- Author:
Yonghong BAI
- Publication Type:Journal Article
- Keywords:
Adriamycin;
Dilated cardiomyopathy;
Rabbit;
Model
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility of adriamycin-induced dilated cardiomyopathy model in rabbits.Methods:26 rabbits were given 1mg.kg-1 body wt.of adriamycin intravenously twice a week for 8 weeks,then received echocardiography and histoligical examination after 3 weeks of final injection.Results: 17 rabbits survived.Compared to the baseline station,the value for the Left ventricular diastolic dimension(LVEDD) and the Left ventricular systolic dimension(LVESD) increased significantly,while the value for the Left ventricular ejection fraction(LVEF)and the Left ventricular short fraction(LVFS) decreased significantly after treated with adriamycin(P
