Study on the effects of exogenous quinolinic acid on acute and subacute inflammation in animal models
- VernacularTitle:外源性给予喹啉酸对急性和亚急性炎症动物模型的作用
- Author:
Yin XIONG
- Publication Type:Journal Article
- Keywords:
Quinolinic acid;
Inflammation
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
Objective: To investigate the anti-inflammatory effects of quinolinic acid.Methods: Kunming mouse or Wistar rat was selected to proceed experiments.Influences of quinolinic acid on tumidness caused by dimethylbenzene in mouse's ear,on wandering of rat WBC caused by CMC injection,on increasement of mouse capillary vessel permeability caused by acetic acid,on granuloma in rat's armpit caused by tampon and phagocytosis of mouse were investigated,respectively.Results: Obvious suppression of all the inflammatory models was observed.Conclusion:Exogenous quinolinic acid is endowed with quite evident anti-inflammatory effects on either acute or subacute animal models with somewhat immunological inhibition.
