Effect of Shenfu on concentration of plasma neuropeptide Y during cardiopulmonary bypass
- VernacularTitle:参附注射液对体外循环患者血浆神经肽浓度变化的影响
- Author:
Su MIN
- Publication Type:Journal Article
- Keywords:
Shenfu injection;
Cardiopulmonary bypass;
Congenital heart disease;
Neuropeptide Y
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of Shenfu on plasma neuropeptide Y in antrial septal defect(ASD) and(or) ventricular septal defect(VSD) of congenital heart disease(CHD) during cardiopulmonary bypass.Methods:20 patients undergoing ASD(VSD) were divided into control group(group C) and trial group(group SF) at random.Each was with 10 patients.Patients in group C accepted routine normal saline fluiding without SFI during CPB.In group SF,1.5ml/kgSFI was pumped via CPB at the time of routine fluiding and after aorta was opened.Monitoring of hemodynamic MAP was done before CPB(t1),and at times of initiating anterior parallel circulation(APC)(t2),of posterior parallel circulation(PPC)(t3) and CPB stopped(t4).Other hemodynamics markers(HR,abnormal ECG-ST) were recorded after restoration of heart beat.Blood samples were taken from central vein to determine the serum concentrations of cardiac neuropeptide Y(NPY).Results: 1.The change of hemodynamics: MAP,HR of Group SF were higher than those of group C(P
